Operational Medicine 2001 Field Medical Service School Student Handbook: Molle medical bag/surgical instrument set". December 7, 1999 . Retrieved June 27, 2007. EDT’s are not as highly concentrated in oils and elixirs as an EDP or Perfume would be and contain one to three per cent of fragrance oils. This impacts the ability of the fragrance to last and around eighty percent of the oils in an EDT fragrance will evaporate within three hours of application. Musto, David F. The American Disease: Origins of Narcotic Control. New York: Oxford University Press, 1987. Extensive textual and pictorial sources also show that poppy cultivation and opium consumption were widespread in Safavid Iran [42] and Mughal India. [43] England [ edit ]

Morphine was first synthesised from opium in 1805 by a German chemist and was advertised as a new wonder medicine that was non-addictive and could even be used for the treatment of opium dependence. About 1850, the hypodermic syringe came into use and at that time people believed that smoking opium, rather than injecting opiates led to dependence. Thousands of soldiers in the American Civil War came home addicted to morphine given to them to ease the pain of their injuries. In 1874, again in Germany, heroin was first made from morphine – again it was advertised as non-addictive, this time as a substitute for morphine. Once extracted, opium contains two main groups of alkaloids; the psychoactive constituents which are in the category of phenanthrenes and alkaloids that have no central nervous system effect in the category of isoquinolines. Morphine is the most prevalent and principal alkaloid in opium, and it is responsible for most of the harmful effects of opium. 14 Joyce A. Madancy (April 2004). "The Troublesome Legacy of Commissioner Lin" . Retrieved September 25, 2007.

Ladenburg, Thomas (1974). "Chapter 1, The French in Indochina" (PDF). University of Houston. Archived (PDF) from the original on March 1, 2023 . Retrieved March 21, 2023.

Smoking of opium came on the heels of tobacco smoking and may have been encouraged by a brief ban on the smoking of tobacco by the Ming emperor. The prohibition ended in 1644 with the coming of the Qing dynasty, which encouraged smokers to mix in increasing amounts of opium. [1] In 1705, Wang Shizhen wrote, "nowadays, from nobility and gentlemen down to slaves and women, all are addicted to tobacco." Tobacco in that time was frequently mixed with other herbs (this continues with clove cigarettes to the modern day), and opium was one component in the mixture. Tobacco mixed with opium was called madak (or madat) and became popular throughout China and its seafaring trade partners (such as Taiwan, Java, and the Philippines) in the 17th century. [47] In 1712, Engelbert Kaempfer described addiction to madak: "No commodity throughout the Indies is retailed with greater profit by the Batavians than opium, which [its] users cannot do without, nor can they come by it except it be brought by the ships of the Batavians from Bengal and Coromandel." [20]Speer, William (1870). The oldest and the newest empire: China and the United States. Hartford, Conn., S. S. Scranton and company; Philadelphia, Parmelee & co.; [etc., etc.]

Ahmad, Diana L. The Opium Debate and Chinese Exclusion Laws in the Nineteenth-century American West (University of Nevada Press, 2007). Drugs and Racism in the Old West.Trafkowski, J; Madea, B; Musshoff, F (August 2006). "The significance of putative urinary markers of illicit heroin use after consumption of poppy seed products". Therapeutic Drug Monitoring. 28 (4): 552–8. doi: 10.1097/00007691-200608000-00011. PMID 16885724. S2CID 22585610.