In December 2010, its use was banned in the EU, as the product is based on borate, which the union considers "carcinogenic, mutagenic, or toxic for reproduction". Amosan was originally made by Oral-B; a mention of the powder appeared in the February 6, 1970 Federal Register.

An 1979 recent double-blind crossover study [9] suggests that hydrogen peroxide, which is released during the use of this product, may prevent or retard colonization and multiplication of anaerobic bacteria, such as those that inhabit oral wounds. Vintage Brands Limited began manufacturing and selling Amosan Oral Antiseptic Rinse in 2014 because many consumers were disappointed that it was no longer available. To use it, dissolve the contents of one sachet in 30ml warm water, and rinse your mouth with half of the solution for 30 seconds, expel it and repeat.

The active ingredient, sodium perborate monohydrate, is quickly hydrolyzed into hydrogen peroxide and borate on contact with water. Ingredients: Sodium perborate monohydrate (active ingredient), ginger flavour, L-tartaric acid, menthol, peppermint flavour, sodium saccharin, vanilla flavour. It is used to aid in the prevention of, as well as speed the recovery from canker sores, denture irritation, orthodontic irritation, and oral injuries or after dental procedures.