Regelle provides immediate comfort and long lasting relief from common symptoms. of vaginal atrophy. The polycarbophil-carbopol based vaginal gel has a high level of bio-adhesiveness capable of ensuring a prolonged moisturising action on the epithelium of the vaginal mucous membrane 2. This gel is capable of adhering to the vaginal mucous membranes thanks to the presence of two characteristic polyacid polymers having a high molecular weight and a molecular structure very similar to that of the vaginal mucous: Polycarbophil and carbopol 2. Polycarbophil is hydrophilic and provides direct cellular ‘moisturising’ action resulting from an increased flow of water molecules from outside to the inside of the cells on the surface of vaginal mucous membrane. This action creates a moist film over the vaginal wall hydrating the underlying mucosa 3. This movement of water into the cells of the vaginal epithelium is promoted by the particular unique structure of the polymers in this gel 2. Being bio-adhesive, Regelle has been shown in laboratory and clinical studies to adhere to tissue for 24-72h, resulting in diffusion of water from the gel to the underlying vaginal mucosa 3.
Furthermore, polycarbophil and carbopol are substances with a buffering action and their use in women experiencing menopause either naturally or as a result of surgery has led to a correction of the vaginal pH values comparable to those obtained with hormone replacement therapy 4.
The pH of the polycarbophil gel is 3.0 and it buffers to a normal vaginal pH of 3.5 to 5.0 3. Rejuvenates: Regelle also improves the elasticity of the vaginal wall, encourages the return of natural secretions and restores the natural pH of the vagina. Gelfand, M et al (1994) Treating Vaginal Dryness in Brest Cancer Patients: Results of Applying a Polycarbophil Moisturizing Gel. Journal of Women’s Health; volume 3, Number 6, p427-433# Easy to Use: Each box of Regelle contains either 3, 6 or 12 individual Applicators .The applicator is simply inserted into the vagina, squeezed, then removed and discarded. The single use applicator delivers moisture where it is needed.

Painful Sexual Intercourse:Regelle provides immediate relief while rejuvenating natural secretions and improving the elasticity of vaginal walls. Our research shows that intimate dryness can be an issue for many women at a number of ‘hormonal & life-stage moments’ during their lives – not exclusively during the menopause. Indeed, many women report suffering dryness when taking oral contraceptives, during periods of stress, during medical treatments such as chemotherapy and even during breastfeeding. Regelle ® is a long lasting vaginal moisturiser intended for the symptomatic relief of vaginal atrophy, dryness, itching, irritation and discomfort. Nachtigall, L.E (1994) Comparative study: Replens versus local estrogen in menopausal women. Fertility and Sterility.Volume 61, Number 1, p 178-180.Furthermore, polycarbophil and carbopol are substances with a buffering action and their use in women experiencing menopause either naturally or as a result of surgery has led to a correction of the vaginal pH values comparable to those obtained with hormone replacement therapy 4. It is estimated that up to 40% of your post-menopausal patients may need your advice but are simply too embarrassed to ask. Furthermore, even if you are prescribing HRT to your patients, it is shown that 25% of menopausal women who take hormone replacement therapy continue to present with the signs and symptoms of vaginal atrophy. 1 Due to a lengthening of the average lifespan and longer life expectancy after menopause, vaginal atrophy is destined to become a clinical problem with an increasingly greater epidemiological significance. The seriousness of this menopausal symptom should not be minimized, as vaginal dryness represents an uncomfortable problem, with physical and psychological consequences that can have a deleterious impact on the patient’s quality of life.

Regelle ® is so safe patients can use it confidently for years, even decades, and with regular use some women may find that fewer applications are needed, because the dryness reduces. A recent survey of 500 women in Ireland reported 7 out of 10 experience the painful debilitating effects of vaginal dryness at some stage. However, 59% of sufferers do not seek help from their GP or healthcare professional. Almost 20%, quoted embarrassment as a factor in not seeking help, and a further 13% assumed their condition would go away. Regelle is a water-based intravaginal gel that is clinically proven to provide soothing, continuous moisture, giving relief from symptoms of vaginal dryness, atrophy, itching, irritation and discomfort. Regelle is a NON-hormonal preparation and can be used in conjunction with systemic hormone replacement therapy (HRT).Regular use of Regelle, once every 3 days, can help maintain vaginal health and comfort by replenishing essential vaginal moisture before and after menopause. In a study by Gelfand et al (1994) treating vaginal dryness in breast Cancer Patients Polycarbophil Moisturising gel show that a polycarbophil vaginal moisturiser gel effectively relieves vaginal dryness in most patients without causing significant side effects. This study also showed a statistically significant reduction in mean vaginal pH and improvement in overall vaginal elasticity scores, as well as significant improvement in vaginal health measures at each monthly interval. Immediate Relief: Regelle provides immediate comfort and long-lasting relief from symptoms of vaginal dryness.Can be use with HRT: Regelle is also suitable for use by patients taking systemic Hormone Replacement Therapy (HRT).

One application (2.5 g) to be inserted into the vagina every three days, preferably in the morning. For millions of women, vaginal dryness is a real problem that affects and interferes with their day-to-day lives. Women may experience dryness during the menopause, times of stress or as a side effect of certain medications and medical treatments. The effects of vaginal dryness vary from woman to woman, ranging from minor discomfort to painful sexual intercourse. Regardless of the level of discomfort, vaginal dryness can impact your daily life. Easy to Use: Each box of regelle contains either 3, 6 or 12 individual Applicators The applicator is simply inserted into the vagina, squeezed, then removed and discarded. The single use applicator delivers moisture where it is needed.

Physical symptoms of vaginal dryness include itching, pain and discomfort, while 36% of women in the survey said that vaginal dryness even made exercising uncomfortable. Healthcare Professional e.g. Pharmacist, GP Through a friend From an advert Internet Other 3. Prior to using Regelle, what were your symptoms? (Dryness, pain or discomfort during intercourse etc..) Regelle works by lining the inside of the vagina, providing moisturisation, lubrication and comfort 1. Bachmann, G.A et al (1992) Long Term Nonhormonal Treatment of Vaginal Dryness. Clinical Practice in Sexuality; Volume 8, Number 8/9, p 3-8 High Street Pharmacy (Boots, Lloyds) Local independent Pharmacy Supermarket Online Pharmacy Online directly from Kora Healthcare 9. Have you any Additional Comments about Regelle?