Joined in 2023 
82 
63 About this deal
High in VITAMIN C - Vitamin C is important for immune function. It is involved in the normal formation of collagen for the normal function of the skin. The skin acts as a barrier and helps to protect the body from infection. Food supplements are intended to supplement the diet and should not be substituted for a varied diet or healthy lifestyle. Selenium is important for the proper functioning of your thyroid gland. In fact, thyroid tissue contains a higher amount of selenium than any other organ in the human body ( 21). Rees K, Hartley L, Day C, Flowers N, Clarke A, Stranges S. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013 Jan 31;(1):CD009671. [ PubMed abstract]
The results of observational studies are mixed [ 55]. In two large studies, participants with lower plasma selenium levels at baseline were more likely to experience cognitive decline over time, although whether the participants in these studies were selenium deficient is not clear [ 53, 56, 57]. An analysis of NHANES data on 4,809 older adults in the United States found no association between serum selenium levels (which ranged from lower than 11.3 to higher than 13.5 mcg/dL) and memory test scores [ 58]. Chun OK, Floegel A, Chung SJ, Chung CE, Song WO, Koo SI. Estimation of antioxidant intakes from diet and supplements in U.S. adults. J Nutr 2010;140:317-24. [ PubMed abstract]Selenium is an essential trace mineral that is necessary for many processes and functions in the body like reproduction, thyroid hormone metabolism, DNA synthesis and protection from oxidative damage and infection. Selenium is considered as essential because it is only obtained through our dietary intake. It is found naturally occurring in a variety of food sources with seafood and organ meats being the richest sources of this mineral. Other sources include muscle meats, cereals, grains and dairy products. Recent research however has proved that average levels of selenium are only marginally adequate and it appears that gaining this mineral from food sources alone could be a challenge.
Selenium concentration is higher in the thyroid gland than in any other organ in the body, and, like iodine, selenium has important functions in thyroid hormone synthesis and metabolism.
Most adults can tolerate up to 100–800 mg a day of vitamin E, but long-term intake of large doses (more than 1,000 mg daily) can cause headaches, nausea, blurred vision and disturbed functions of the thyroid gland. Recently, it has been recommended that high-dose intake of vitamin E (more than 400 mg a day) should be avoided. This has been attributed to selenium’s ability to reduce DNA damage and oxidative stress, boost your immune system, and destroy cancer cells ( 8). Long-term use of selenium in doses greater than 400 micrograms (mcg) per day can lead to serious medical problems or death. Do not use more of this product than is recommended on the label. However, some research suggests that supplementing with selenium may reduce side effects in people undergoing radiation therapy.
Kupka R, Garland M, Msamanga G, Spiegelman D, Hunter D, Fawzi W. Selenium status, pregnancy outcomes, and mother-to-child transmission of HIV-1. J Acquir Immune Defic Syndr 2005;39:203-10. [ PubMed abstract] Hurwitz BE, Klaus JR, Llabre MM, Gonzalez A, Lawrence PJ, Maher KJ, et al. Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation: a randomized controlled trial. Arch Intern Med 2007;167:148-54. [ PubMed abstract] For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement. Selenium levels are significantly lower in patients undergoing long-term hemodialysis than in healthy individuals. Hemodialysis removes some selenium from the blood [ 24]. In addition, hemodialysis patients are at risk of low dietary selenium intakes due to anorexia resulting from uremia and dietary restrictions. Although selenium supplementation increases blood levels in hemodialysis patients, more evidence is needed to determine whether supplements have beneficial clinical effects in these individuals. People living with HIV Breast milk, formula, and food should be the only sources of selenium for infants. Interactions with Medications
Customer Reviews for Selenium plus A,C,E
Asthma has been associated with increased levels of oxidative stress and inflammation in the body ( 29). If you need surgery, tell the surgeon ahead of time that you are using selenium. You may need to stop using this product for at least 2 weeks before your surgery. Side effects. Taken at normal doses, selenium doesn't usually have side effects. An overdose of selenium may cause bad breath, hair loss, fever, tiredness, and nausea . Selenoproteins help prevent the oxidative modification of lipids, reducing inflammation and preventing platelets from aggregating [ 9]. For these reasons, experts have suggested that selenium supplements could reduce the risk of cardiovascular disease or deaths associated with cardiovascular disease. Campa A, Shor-Posner G, Indacoche F, Zhang G, Lai H, Asthana D, Scott GB, Baum MK. Mortality risk in selenium-deficient HIV-positive children. J Acquir Immune Defic Syndr Hum Retrovirol 1999;15:508-13.
Epidemiological studies have suggested an inverse association between selenium status and the risk of colorectal, prostate, lung, bladder, skin, esophageal, and gastric cancers [ 37]. In a Cochrane Review of selenium and cancer prevention studies, compared with the lowest category of selenium intake, the highest intake category had a 31% lower cancer risk and 45% lower cancer mortality risk as well as a 33% lower risk of bladder cancer and, in men, 22% lower risk of prostate cancer [ 37]. The authors found no association between selenium intake and risk of breast cancer. A meta-analysis of 20 epidemiologic studies showed a potential inverse association between toenail, serum, and plasma selenium levels and prostate cancer risk [ 38]. In both the second trial (41 people over a three-week period) and the third trial (85 people over a three-week period), there was no significant difference between participants allocated 1,200 mg a day vitamin E supplements or participants given 150 mg diclofenac (a non-steroidal anti-inflammatory drug) a day in all aspects of disease severity at the end of the trial.The FNB has established ULs for selenium from food and supplements based on the amounts of selenium that are associated with hair and nail brittleness and loss (see Table 3) [ 6]. Table 3: Tolerable Upper Intake Levels (ULs) for Selenium [ 6]* Age Kupka R, Mugusi F, Aboud S, Hertzmark E, Spiegelman D, Fawzi WW. Effect of selenium supplements on hemoglobin concentration and morbidity among HIV-1-infected Tanzanian women. Clin Infect Dis 2009;48:1475-8. [ PubMed abstract] Sunde RA. Selenium. In: Bowman B, Russell R, eds. Present Knowledge in Nutrition. 9th ed. Washington, DC: International Life Sciences Institute; 2006:480-97 Selenium plays an essential role in treating dermatologic conditions. Selenium sulfide administration is typicallydone via a topical lotion, foam, orshampoo. The main dermatologic indications include tinea versicolor, seborrheic dermatitis of the scalp, dandruff, and hyperkeratosis. [7] [8] [9] [10]Intact skin does not absorb any of the topical selenium. Berr C, Balansard B, Arnaud J, Roussel AM, Alpérovitch A. Cognitive decline is associated with systemic oxidative stress: the EVA study. Etude du Vieillissement Artériel. J Am Geriatr Soc 2000;48:1285-91. [ PubMed abstract]
Great Deal 
New Comment